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Tenm3tm1Cal
Targeted Allele Detail
Nomenclature
Symbol: Tenm3tm1Cal
Name: teneurin transmembrane protein 3; targeted mutation 1, Catherine A Leamey
MGI ID: MGI:3767554
Synonyms: Ten3delta4, Ten_m3 KO
Gene: Tenm3  Location: Chr8:48680717-49296986 bp, - strand  Genetic Position: Chr8, 27.02 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:128389
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 4, encoding the trans-membrane domain was disrupted by the insertion of a neomycin cassette. Quantitative PCR analysis indicated that transcript expression was significantly reduced in homozygous mice. Western blot analysis confirmed the absence of protein in brain lysates from homozygous mice. (J:128389)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tenm3 Mutation:  158 strains or lines available
References
Original:  J:128389 Leamey CA, et al., Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision. PLoS Biol. 2007 Sep;5(9):e241
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory