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Targeted Allele Detail
Symbol: Cdkn2btm2Brn
Name: cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); targeted mutation 2, Anton Berns
MGI ID: MGI:3767459
Synonyms: Ink4ab-
Gene: Cdkn2b  Location: Chr4:89306289-89311032 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Germline Transmission:  Earliest citation of germline transmission: J:125189
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExons 1 and 2 were replaced with a PGK-hyg cassette with a 5' loxP site in ES cells containing the Cdkn2atm1.1Brn. Integration occurred on the chromosome that contained the wild-type Cdkn2atm1.1Brn allele. The absence of the p15Ink4b and p16Ink4a protein products was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:125189)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2b Mutation:  2 strains or lines available
Original:  J:125189 Krimpenfort P, et al., p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature. 2007 Aug 23;448(7156):943-6
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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