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Gabrb3tm2.1Geh
Targeted Allele Detail
Nomenclature
Symbol: Gabrb3tm2.1Geh
Name: gamma-aminobutyric acid (GABA) A receptor, subunit beta 3; targeted mutation 2.1, Gregg E Homanics
MGI ID: MGI:3767248
Synonyms: beta3F
Gene: Gabrb3  Location: Chr7:57590518-57828802 bp, + strand  Genetic Position: Chr7, 33.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127877
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsGabrb3tm2Geh heterozygous mice with a floxed exon 3 and neomycin cassette allele (Fneo) were bred to Tg(ACTFLPe)9205Dym actin-FLPe mice to remove the Neomycin cassette. (J:127877)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabrb3 Mutation:  7 strains or lines available
References
Original:  J:127877 Ferguson C, et al., New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout. BMC Neurosci. 2007;8:85
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory