Gabrb3^tm2.1Geh
Targeted Allele Detail

Summary

• Symbol: Gabrb3^tm2.1Geh
• Name: GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3; targeted mutation 2.1, Gregg E Homanics
• MGI ID: MGI:3767248
• Synonyms: beta3^F
• Gene: Gabrb3 Location: Chr7:57240266-57478550 bp, + strand Genetic Position: Chr7, 33.53 cM
• Alliance: Gabrb3^tm2.1Geh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127877
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Gabrb3^tm2Geh heterozygous mice with a floxed exon 3 and neomycin cassette allele (Fneo) were bred to Tg(ACTFLPe)9205Dym actin-FLPe mice to remove the Neomycin cassette. (J:127877)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gabrb3 Mutation: 30 strains or lines available

References

• Original: J:127877 Ferguson C, et al., New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout. BMC Neurosci. 2007;8:85
• All: 14 reference(s)