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Targeted Allele Detail
Symbol: Ctsktm1Mbs
Name: cathepsin K; targeted mutation 1, Mitchell B Schaffler
MGI ID: MGI:3767171
Synonyms: CatK-
Gene: Ctsk  Location: Chr3:95499256-95509362 bp, + strand  Genetic Position: Chr3, 40.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:128098
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 - 5, including the transcription start site, were replaced with a neo cassette via homologous recombination. Immunohistochemical analysis confirmed the absence of detectable protein in femurs from 10 week old homozygous mice. (J:128098)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctsk Mutation:  13 strains or lines available
Original:  J:128098 Li CY, et al., Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass. J Bone Miner Res. 2006 Jun;21(6):865-75
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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