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Targeted Allele Detail
Symbol: Selltm2Alb
Name: selectin, lymphocyte; targeted mutation 2, Arthur L Beaudet
MGI ID: MGI:3767069
Synonyms: E/P/I
Gene: Sell  Location: Chr1:164061982-164084181 bp, + strand  Genetic Position: Chr1, 71.37 cM
Germline Transmission:  Earliest citation of germline transmission: J:70682
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe Sell gene was disrupted by insertion of a puromycin resistance cassette in opposite orientation into the coding sequence via homologous recombination. The construct was injected into ES cells already carrying mutations in Sele and Selp. Clones where the targeting vector inserted in cis to the Sele and Selp mutations were used to produce triple selectin-null mutant mice. (J:70682)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sell Mutation:  28 strains or lines available
Original:  J:70682 Collins RG, et al., Dermal and pulmonary inflammatory disease in E-selectin and P-selectin double-null mice is reduced in triple-selectin-null mice. Blood. 2001 Aug 1;98(3):727-35
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory