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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm3(phiC31*)Sor
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Philippe Soriano
MGI ID: MGI:3766932
Synonyms: R26phiC31o
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:128069
Parent Cell Line:  AK7.1 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
Mutation detailsA targeting construct with the SA-PhiC31opA-PGKneopA cassette, which contains the mouse codon-optimized site-specific recombinase PhiC31o sequence (with a C-terminal SV40 nuclear localization signal) driven by the phosphoglycerate kinase 1 (PGK) promoter, and bovine growth hormone polyadenylation (bpA) sequence was inserted into the Gt(ROSA)26Sor locus. Flp-mediated recombination removes the neo cassette. PhiC31o-mediated recombination in mice carrying containing a sequence of interest flanked by attB and attP sites results in tissue-specific deletion of the targeted sequence. (J:128069)
 Tissue activity of this recombinase allele
Driver: Gt(ROSA)26Sor     Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  534 strains or lines available
Original:  J:128069 Raymond CS, et al., High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells. PLoS One. 2007;2(1):e162
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory