Tg(Tnf*)A86Gkl
Transgene Detail

Summary

• Symbol: Tg(Tnf*)A86Gkl
• Name: transgene insertion A86, George Kollias
• MGI ID: MGI:3766228
• Synonyms: TgA86
• Transgene: Tg(Tnf*)A86Gkl Location: unknown
• Alliance: Tg(Tnf*)A86Gkl page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tnf*)A86Gkl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnf (MGI:104798)

• Mutation details: This transgenic line expresses a mouse Tnf gene containing a deletion mutation of the codons encoding the 1st to the 12th amino acids of the mature 17-kDa TNF protein. This mutant TNF gene has previously been shown to produce a transmembrane TNF protein that remains bioactive against cellular targets in vitro and in vivo. Approximately 50 copies of the transgene were inserted. Northern analysis demonstrated transgene expression in thymus, mesenteric lymph nodes, spleen, kidney, liver, heart, brain, skin and joints. The expressed protein was undetectable in serum as determined by ELISA assays. (J:43603)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:43603 Alexopoulou L, et al., A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling. Eur J Immunol. 1997 Oct;27(10):2588-92
• All: 4 reference(s)