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Transgene Detail
Symbol: Tg(COL1A1)73Prc
Name: transgene insertion 73, Darwin J Prockop
MGI ID: MGI:3766089
Synonyms: line V
Transgene: Tg(COL1A1)73Prc  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(COL1A1)73Prc expresses 1 gene
Mutation detailsThese mice express a mini-gene construct that contains the 5'- and 3'-ends of the human gene for the pro-alpha(1) collagen chain but lack a large central region containing 41 exons. The mini-gene includes 2.5 kilobases of the 5'-promoter region, the first 5 exons and introns, the last 6 exons and introns, and about 2 kilobases of the 3"flanking region. The junction between the 5'- and 3'-halves of the mini-gene was made in introns so as to preserve the consensus sequences for RNA splicing. Mice in this line carry about 20 copies of the transgene. (J:31417, J:146429)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:31417 Khillan JS, et al., Transgenic mice that express a mini-gene version of the human gene for type I procollagen (COL1A1) develop a phenotype resembling a lethal form of osteogenesis imperfecta. J Biol Chem. 1991 Dec 5;266(34):23373-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.20
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