Cdkn2btm1Brn
Targeted Allele Detail
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Symbol: |
Cdkn2btm1Brn |
Name: |
cyclin dependent kinase inhibitor 2B; targeted mutation 1, Anton Berns |
MGI ID: |
MGI:3766012 |
Synonyms: |
Ink4b-, p15Ink4b |
Gene: |
Cdkn2b Location: Chr4:89224536-89229276 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
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Alliance: |
Cdkn2btm1Brn page
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Germline Transmission: |
Earliest citation of germline transmission:
J:125189
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 2, encoding amino acids 44-130, was replaced by a hygromycin cassette. The absence of only the p15Ink4b protein product was confirmed by western blot analysis on mouse embryonic fibroblasts.
(J:125189)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cdkn2b Mutation: |
7 strains or lines available
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Original: |
J:125189 Krimpenfort P, et al., p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature. 2007 Aug 23;448(7156):943-6 |
All: |
4 reference(s) |
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