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Cdkn2btm1Brn
Targeted Allele Detail
Nomenclature
Symbol: Cdkn2btm1Brn
Name: cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); targeted mutation 1, Anton Berns
MGI ID: MGI:3766012
Synonyms: Ink4b-, p15Ink4b
Gene: Cdkn2b  Location: Chr4:89306289-89311032 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125189
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, encoding amino acids 44-130, was replaced by a hygromycin cassette. The absence of only the p15Ink4b protein product was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:125189)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2b Mutation:  1 strain or line available
References
Original:  J:125189 Krimpenfort P, et al., p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature. 2007 Aug 23;448(7156):943-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory