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Fbxl20tm1Seto
Targeted Allele Detail
Nomenclature
Symbol: Fbxl20tm1Seto
Name: F-box and leucine-rich repeat protein 20; targeted mutation 1, Mitsutoshi Setou
MGI ID: MGI:3765911
Gene: Fbxl20  Location: Chr11:98082556-98150403 bp, - strand  Genetic Position: Chr11, 61.69 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127941
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 and part of exon 4 were replaced by a neo cassette resulting in the loss of the F-box domain and a frame shift. The loss of protein product was confirmed by western blot analysis on hippocampus extracts. (J:127941)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fbxl20 Mutation:  25 strains or lines available
References
Original:  J:127941 Yao I, et al., SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell. 2007 Sep 7;130(5):943-57
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/11/2017
MGI 6.08
The Jackson Laboratory