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Ncor2tm1Rsd
Targeted Allele Detail
Nomenclature
Symbol: Ncor2tm1Rsd
Name: nuclear receptor co-repressor 2; targeted mutation 1, Michael G Rosenfeld
MGI ID: MGI:3765904
Synonyms: SMRT-
Gene: Ncor2  Location: Chr5:125017153-125179219 bp, - strand  Genetic Position: Chr5, 63.96 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127720
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2 kb region containing 4 exons that encode amino acids 1038 to 1198 was replaced with a beta-globin/PGK-neo cassette. The absence of protein product was confirmed by western blot analysis. (J:127720)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ncor2 Mutation:  139 strains or lines available
References
Original:  J:127720 Jepsen K, et al., SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature. 2007 Nov 15;450(7168):415-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory