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Transgene Detail
Symbol: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Name: transgene insertion 21, Mathias Jucker
MGI ID: MGI:3765351
Synonyms: APPPS1, APP.PS1, APPPS1-21, Tg(Thy1-APP*Swe,Thy1-PSEN1*L166P)21Jckr
Transgene: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr  Location: unknown  
Strain of Origin:  C57BL/6J
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr expresses 2 genes
Mutation detailsThe Thy1-APPKM670/671NL was constructed with the mutant human APPKM670/671NL cDNA (Swedish or KM670/671NL mutation of amyloid precursor protein (APP)) placed downstream of the murine Thy1.2 promoter region. Additionally, the Thy1-PS1L166P transgene was constructed with a mutant human PS1L166P cDNA (leucine to proline mutation at position 166 of human presenilin 1 (Alzheimer disease 3, PSEN1 or PS1)) placed downstream of the murine Thy1.2 promoter sequences. These constructs were coinjected to produce founder mice. In addition to line 21, lines 5 and 8 were also established. (J:116895)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:116895 Radde R, et al., Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep. 2006 Sep;7(9):940-6
All:  80 reference(s)

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MGI 6.12
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