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Tg(CAG-SNCA*)1.1Ccs
Transgene Detail
Summary
Symbol: Tg(CAG-SNCA*)1.1Ccs
Name: transgene insertion 1.1, Christine C Stichel
MGI ID: MGI:3764813
Synonyms: BAsyn, chbetaactin, Tg(ACTB-SNCA*)1.1Ccs, Tg(CAG-SNCA*)1.1Ccs
Transgene: Tg(CAG-SNCA*)1.1Ccs  Location: unknown  
Alliance: Tg(CAG-SNCA*)1.1Ccs page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-SNCA*)1.1Ccs expresses 1 gene
 
Mutation detailsThis transgene contains a double mutant human SNCA with amino acid substitutions of proline for alanine at position 30 (A30P) and threonine for alanine at position 53 (A53T) under the control of a CMV enchanced, chicken beta-actin promoter. Expression is detected in the brain, kidney, lung, liver and heart. (J:127708)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Four lines were created (1.10, 1.1, 1.5 and 1,9) with similar expression patterns and line 1.1 choosen as the representative line.
References
Original:  J:127708 Maskri L, et al., Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice. Neurodegener Dis. 2004;1(6):255-65
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory