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Tg(Pf4-icre)Q3Rsko
Transgene Detail
Nomenclature
Symbol: Tg(Pf4-icre)Q3Rsko
Name: transgene insertion Q3, Radek C Skoda
MGI ID: MGI:3764698
Synonyms: (Pf4)-Cre, Pf4-Cre, Tg(Cxcl4-cre)Q3Rsko, Tg(Pf4-cre)Q3Rsko
Transgene: Tg(Pf4-icre)Q3Rsko  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsA transgene was created from a BAC where cre-recombinase is driven by the Cxcl4 (Platelet factor 4) promoter. This transgene also contains the Cxcl3, Cxcl5, Ppbp, and Cxcl15 genes. This line has one copy of the transgene inserted with expression restricted to megakaryocytes and platelets, as demonstrated by RT-PCR and Western blotting. (J:127229)
Recombinase
activity
Activity:
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Driver: Pf4     Summary of all recombinase alleles driven by Pf4.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:127229 Tiedt R, et al., Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo. Blood. 2007 Feb 15;109(4):1503-6
All:  179 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory