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Itgb7tm1Mshi
Targeted Allele Detail
Nomenclature
Symbol: Itgb7tm1Mshi
Name: integrin beta 7; targeted mutation 1, Motomu Shimaoka
MGI ID: MGI:3764672
Synonyms: Itgb7D146A
Gene: Itgb7  Location: Chr15:102215995-102231944 bp, - strand  Genetic Position: Chr15, 57.39 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127413
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Constitutively active)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA vector consisting of a cre recombinase and a neomycin resistant gene under the control of the sperm-specific ACE promoter was used for targeting exon 4. In exon 4, the sequence encoding amino acid 146 was changed from an aspartate to an alanine (D146A). This mutation was predicted to keep the integrin in a constitutively adhesive state. The cre-recombinase and the neomycin resistance gene were excised in chimeras during spermatogenesis, leaving behind one loxP site. The mutation was confirmed by genomic sequencing. (J:127413)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb7 Mutation:  54 strains or lines available
References
Original:  J:127413 Park EJ, et al., Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. J Clin Invest. 2007 Sep;117(9):2526-38
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory