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Ptch1tm1Hahn
Targeted Allele Detail
Nomenclature
Symbol: Ptch1tm1Hahn
Name: patched 1; targeted mutation 1, Heidi Hahn
MGI ID: MGI:3764517
Synonyms: Ptchflox
Gene: Ptch1  Location: Chr13:63508328-63573598 bp, - strand  Genetic Position: Chr13, 32.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127207
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted into intron 7 and a second loxP site followed by a frt-flanked neo cassette was inserted into intron 9. Insertion was confirmed by Southern blot analysis and PCR genotyping. (J:127207)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptch1 Mutation:  83 strains or lines available
References
Original:  J:127207 Uhmann A, et al., The Hedgehog receptor Patched controls lymphoid lineage commitment. Blood. 2007 Sep 15;110(6):1814-23
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory