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Tg(Myh6-MT2A)15Pne
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-MT2A)15Pne
Name: transgene insertion 15, Paul N Epstein
MGI ID: MGI:3763353
Synonyms: MT, MT-TG, My-MT-IIa
Transgene: Tg(Myh6-MT2A)15Pne  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-MT2A)15Pne expresses 1 gene
 
Mutation detailsThis transgene contains human MT2A under the control of the Myh6 promoter along with the first 2 introns and the first three non-coding exons. Expression is cardiac-specific. (J:100354)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
4 lines containing this transgene were created (12, 15, 07 and 01) with over-expression 10- or 130-fold higher than baseline. Identical phenotypes were observed in mice over-expressing 10-fold (line 15) or 130-fold (line 01) higher than baseline. Line 15 was chosen as the representative line.
References
Original:  J:100354 Kang YJ, et al., Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity. J Clin Invest. 1997 Sep 15;100(6):1501-6
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory