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Transgene Detail
Symbol: Tg(Itgax-cre)1-1Reiz
Name: transgene insertion 1-1, Boris Reizis
MGI ID: MGI:3763248
Synonyms: Cd11c-cre, CD11cCre, CD11cCreT
Transgene: Tg(Itgax-cre)1-1Reiz  Location: unknown  
Alliance: Tg(Itgax-cre)1-1Reiz page
Lupus-like autoimmune disease in Lyntm1Sor/Lyntm1Sor and Lyntm1.1Calo/Lyntm1.1Calo Top2aGt(PST14568)Mfgc/0 mice

Show the 3 phenotype image(s) involving this allele.

Strain of Origin:  (C57BL/6 x CBA)F1
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
Mutation detailsA transgenic construct containing sequence encoding cre recombinase under the control of the mouse integrin alpha X (Cd11c) promoter, and a bovine growth hormone poly A signal sequence, was introduced into B6CBAF1/J donor eggs. BAC clone RP24-361C4 (BACPAC Resources) containing the Itgax (Cd11c) gene but lacking the 5' end of the adjacent Itgam gene, was modified by ET recombination to generated the transgene construct. Founder line 1-1 was consequently established. Cre recombinase expression is detected in CD8-, CD8+ dendritic cells, tissue derived dendritic cells from lymph nodes, lung and epidermis and plasmacytoid dendritic cells. Background recombination is detected in lymphocytes (<10%) and myeloid cells (<1%). (J:125869)
 Tissue activity of this recombinase allele
Driver: Itgax (mouse)
Summary of all recombinase alleles driven by Itgax.

View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Original:  J:125869 Caton ML, et al., Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. J Exp Med. 2007 Jul 9;204(7):1653-64
All:  557 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
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