Tg(Itgax-cre)1-1Reiz
Transgene Detail
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Symbol: |
Tg(Itgax-cre)1-1Reiz |
Name: |
transgene insertion 1-1, Boris Reizis |
MGI ID: |
MGI:3763248 |
Synonyms: |
Cd11c-cre, CD11cCre, CD11cCreT |
Transgene: |
Tg(Itgax-cre)1-1Reiz Location: unknown
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Alliance: |
Tg(Itgax-cre)1-1Reiz page
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Lupus-like autoimmune disease in Lyntm1Sor/Lyntm1Sor and Lyntm1.1Calo/Lyntm1.1Calo Top2aGt(PST14568)Mfgc/0 mice
Show the 3 phenotype image(s) involving this allele.
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Transgene Type: |
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Transgenic (Recombinase) |
Mutation: |
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Insertion
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Tg(Itgax-cre)1-1Reiz expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Itgax (MGI:96609) |
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Mutation details: A transgenic construct containing sequence encoding cre recombinase under the control of the mouse integrin alpha X (Cd11c) promoter, and a bovine growth hormone poly A signal sequence, was introduced into B6CBAF1/J donor eggs. BAC clone RP24-361C4 (BACPAC Resources) containing the Itgax (Cd11c) gene but lacking the 5' end of the adjacent Itgam gene, was modified by ET recombination to generated the transgene construct. Founder line 1-1 was consequently established. Cre recombinase expression is detected in CD8-, CD8+ dendritic cells, tissue derived dendritic cells from lymph nodes, lung and epidermis and plasmacytoid dendritic cells. Background recombination is detected in lymphocytes (<10%) and myeloid cells (<1%).
(J:125869)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Itgax
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 4 strains available
Cell Lines: 0 lines available
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Original: |
J:125869 Caton ML, et al., Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. J Exp Med. 2007 Jul 9;204(7):1653-64 |
All: |
635 reference(s) |
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