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Targeted Allele Detail
Symbol: Tacc3tm1.2Tno
Name: transforming, acidic coiled-coil containing protein 3; targeted mutation 1.2, Tetsuo Noda
MGI ID: MGI:3763219
Synonyms: Tacc3D
Gene: Tacc3  Location: Chr5:33658128-33672203 bp, + strand  Genetic Position: Chr5, 17.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:126471
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe genomic region between intron 4 and 5 was removed by cre-mediated recombination following the electroporation of embryonic stem cells with a transient cre-expression construct. The absence of protein product was confirmed by western blot analysis on protein extracted from whole E9.5 embryos. (J:126471)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tacc3 Mutation:  11 strains or lines available
Original:  J:126471 Yao R, et al., TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton. Cancer Sci. 2007 Apr;98(4):555-62
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory