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Ghrltm1Lex
Targeted Allele Detail
Nomenclature
Symbol: Ghrltm1Lex
Name: ghrelin; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:3763213
Gene: Ghrl  Location: Chr6:113716119-113719880 bp, - strand  Genetic Position: Chr6, 52.84 cM, cytoband E3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126636
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 285 bp fragment including the coding region of exon 2 up to exon 3 was replaced with a LacZ-neo cassette. RT-PCR analysis confirms the absence of transcript from the stomach, jejunum, brain, and blood in homozygous mice. (J:126636)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ghrl Mutation:  3 strains or lines available
References
Original:  J:126636 De Smet B, et al., Energy homeostasis and gastric emptying in ghrelin knockout mice. J Pharmacol Exp Ther. 2006 Jan;316(1):431-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory