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Erc1tm1Sud
Targeted Allele Detail
Nomenclature
Symbol: Erc1tm1Sud
Name: ELKS/RAB6-interacting/CAST family member 1; targeted mutation 1, Thomas C Sudhof
MGI ID: MGI:3763189
Synonyms: E1X, ELKS1 KO, ELKS1nc-KO
Gene: Erc1  Location: Chr6:119570796-119848167 bp, - strand  Genetic Position: Chr6, 56.86 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134026
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting vector was designed to flank exon 3 of the gene with loxP sites and insert a FRT-flanked neomycin resistance cassette in intron 3 (within the loxP sites). Resultant carrier mice were crossed with a germline Cre transgenic strain driven by a protamine 1 (Prm1) promoter on a mixed C57BL/6 and 129 background to remove both exon 3 and the neomycin cassette. (J:134026, J:216293)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Erc1 Mutation:  13 strains or lines available
References
Original:  J:134026 Sudhof TC, Generation of an Erc1 knock-out mouse. MGI Direct Data Submission. 2008;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory