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Gja1tm7(Gja2)Kwi
Targeted Allele Detail
Nomenclature
Symbol: Gja1tm7(Gja2)Kwi
Name: gap junction protein, alpha 1; targeted mutation 7, Klaus Willecke
MGI ID: MGI:3763136
Synonyms: Cx4326
Gene: Gja1  Location: Chr10:56377300-56390419 bp, + strand  Genetic Position: Chr10, 28.64 cM
Tubuli seminiferi and ductuli epididymidis of wild type and Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126511
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe open reading frame was replaced with that of Gja2 and a neo cassette flanked by FRT sites. The neo cassette was subsequently removed by Flp-mediated recombination following a cross to Tg(ACTFLPe)9205Dym mice. The replacement of protein products was confirmed by western blot analysis on protein extracts from heart lysates. (J:126511)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gja1 Mutation:  35 strains or lines available
References
Original:  J:126511 Winterhager E, et al., Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart. BMC Dev Biol. 2007;7:26
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory