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Gria1tm4Rlh
Targeted Allele Detail
Nomenclature
Symbol: Gria1tm4Rlh
Name: glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 4, Richard Huganir
MGI ID: MGI:3762912
Gene: Gria1  Location: Chr11:57011571-57330244 bp, + strand  Genetic Position: Chr11, 34.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126784
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation detailsSerines 831, 839, 845 and threonines 838 and 840 were mutated to alanine by PCR mutagenesis prior to homologous recombination. A floxed neo cassette was inserted upstream of the last conding exon was removed by cre-mediated recombination following a cross to mice containing Tg(CMV-cre)1Nagy. Western blot analysis with was performed to confirm the presence of the protein but loss of the phosphorylation sites. (J:126784)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gria1 Mutation:  11 strains or lines available
References
Original:  J:126784 Lee HK, et al., Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors. Mol Cell Neurosci. 2007 Sep;36(1):86-94
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory