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Targeted Allele Detail
Symbol: Irak4tm1Aki
Name: interleukin-1 receptor-associated kinase 4; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3762874
Synonyms: IRAK-4-
Gene: Irak4  Location: Chr15:94543613-94568317 bp, + strand  Genetic Position: Chr15, 48.55 cM, cytoband F1
Germline Transmission:  Earliest citation of germline transmission: J:125729
Parent Cell Line:  GSI-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was constructed so that exon 2 was replaced with a floxed neomycin resistance cassette. Absence of protein was confirmed by western analysis of macrophage extract from homozygotes. (J:125729)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irak4 Mutation:  3 strains or lines available
Original:  J:125729 Kawagoe T, et al., Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. J Exp Med. 2007 May 14;204(5):1013-24
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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