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Irak4tm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Irak4tm1Aki
Name: interleukin-1 receptor-associated kinase 4; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3762874
Synonyms: IRAK-4-
Gene: Irak4  Location: Chr15:94543643-94581815 bp, + strand  Genetic Position: Chr15, 48.55 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125729
Parent Cell Line:  GSI-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was constructed so that exon 2 was replaced with a floxed neomycin resistance cassette. Absence of protein was confirmed by western analysis of macrophage extract from homozygotes. (J:125729)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irak4 Mutation:  4 strains or lines available
References
Original:  J:125729 Kawagoe T, et al., Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. J Exp Med. 2007 May 14;204(5):1013-24
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory