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Targeted Allele Detail
Symbol: Pdcd1lg2tm1.1Lex
Name: programmed cell death 1 ligand 2; targeted mutation 1.1, Lexicon Genetics
MGI ID: MGI:3762772
Synonyms: PD-L2-
Gene: Pdcd1lg2  Location: Chr19:29410919-29471157 bp, + strand  Genetic Position: Chr19, 23.93 cM, cytoband C2-C3
Germline Transmission:  Earliest citation of germline transmission: J:126829
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Project Collection: Lexicon
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsBy homologous recombination a loxP site was inserted 5' of exon2, followed by a NeoR cassette and a 3' loxP site. The resulting mutant mice, Pdcd1lg2tm1Lex were crossed with protamine-Cre transgenic mice to delete exon 2 containing the translational start site. Flow cytometric protein expression analysis confirmed absence of targeted protein expression. (J:126829)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdcd1lg2 Mutation:  8 strains or lines available
Original:  J:126829 Carter LL, et al., PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2007 Jan;182(1-2):124-34
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory