Tg(tetO-Vamp2)1Kdmc
Transgene Detail
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Symbol: |
Tg(tetO-Vamp2)1Kdmc |
Name: |
transgene insertion 1, Ken D McCarthy |
MGI ID: |
MGI:3762765 |
Synonyms: |
dn-SNARE, dominant-negative SNARE, tetO.SNARE |
Transgene: |
Tg(tetO-Vamp2)1Kdmc Location: unknown
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Alliance: |
Tg(tetO-Vamp2)1Kdmc page
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Strain of Origin: |
C57BL/6 x C3H
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Transgene Type: |
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Transgenic (Dominant negative, Inducible, Inserted expressed sequence, Reporter) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Mutation details: The transgene contains the tet operator, tetO, regulating expression of a dominant negative N-ethylmaleimide-sensitive factor attachment protein receptor, or SNARE (dn-SNARE), that blocks the release of neurotransmitters. dn-SNARE is the cytosolic part of the SNARE domain (amino acids 1-96) of vesicle-associated membrane protein 2 (VAMP2; formerly synaptobrevin II). The enhanced green fluorescent protein (EGFP) and E. coli beta-galactosidase (lacZ) reporter genes are also expressed under the control of tetO. The three constructs were co-injected.
(J:102245)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:102245 Pascual O, et al., Astrocytic purinergic signaling coordinates synaptic networks. Science. 2005 Oct 7;310(5745):113-6 |
All: |
16 reference(s) |
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