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Targeted Allele Detail
Symbol: Shank1tm1Shng
Name: SH3 and multiple ankyrin repeat domains 1; targeted mutation 1, Morgan Sheng
MGI ID: MGI:3762757
Gene: Shank1  Location: Chr7:44310253-44360572 bp, + strand  Genetic Position: Chr7, 28.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:132277
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace exons 14 and 15, encoding almost the entire PDZ domain, with a PGK-neomycin drug resistance cassette. The absence of protein product was confirmed by western blot analysis on forebrain membrane extracts. (J:132277)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Shank1 Mutation:  49 strains or lines available
Original:  J:132277 Hung AY, et al., Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. J Neurosci. 2008 Feb 13;28(7):1697-708
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory