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Targeted Allele Detail
Symbol: Kiss1tm1Rla
Name: KiSS-1 metastasis-suppressor; targeted mutation 1, Risto Lapatto
MGI ID: MGI:3762755
Gene: Kiss1  Location: Chr1:133249625-133257460 bp, + strand  Genetic Position: Chr1, 57.91 cM
Germline Transmission:  Earliest citation of germline transmission: J:126704
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was replaced with a neomycin resistance cassette. Southern blotting confirmed recombination but RT-PCR of exon 2 detected a transcript from the gene. Amplification and sequencing of the transcript revealed a previously unknown exon upstream of the targeted exon that was splicing to exon 2. Because no translational start site was found in this sequence, the mutation was predicted not to produce a functional protein. This was confirmed by immunohistochemistry on the hypothalamus. (J:126704)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kiss1 Mutation:  19 strains or lines available
Original:  J:126704 Lapatto R, et al., Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice. Endocrinology. 2007 Oct;148(10):4927-36
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory