About   Help   FAQ
Emx1tm1.1(cre)Ito
Targeted Allele Detail
Nomenclature
Symbol: Emx1tm1.1(cre)Ito
Name: empty spiracles homeobox 1; targeted mutation 1.1, Shigeyoshi Itohara
MGI ID: MGI:3762664
Synonyms: Emx1-Cre KI deltaneo, Emx1tm2(cre)Ito
Gene: Emx1  Location: Chr6:85164913-85181445 bp, + strand  Genetic Position: Chr6, 37.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88421
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA cDNA encoding Cre recombinase with an N-terminal nuclear localization signal (nls) resides immediately 5' of the translation initiation site of the endogenous gene. This allele was derived from Emx1tm1(cre)Ito by FLP recombinase excision of a FRT-flanked pgk-neo cassette that lay immediately downstream of the nls-cre gene. The Emx1 promoter drives Cre recombinase expression in the embryonic through adult dorsal telencephelon; deletion of the selection cassette reportedly prevents ectopic expression in other brain regions. (J:64064, J:104881)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Emx1 (mouse) Summary of all recombinase alleles driven by Emx1.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 45 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Emx1 Mutation:  28 strains or lines available
References
Original:  J:88421 Iwasato T, et al., Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis. 2004 Mar;38(3):130-8
All:  45 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/22/2022
MGI 6.21
The Jackson Laboratory