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Targeted Allele Detail
Symbol: Gatad2atm1Rnu
Name: GATA zinc finger domain containing 2A; targeted mutation 1, Roel Nusse
MGI ID: MGI:3762633
Synonyms: mp66alpha null, p66 KO
Gene: Gatad2a  Location: Chr8:69907076-69996384 bp, - strand  Genetic Position: Chr8, 34.06 cM
Gatad2atm1Rnu/Gatad2atm1Rnu mutant embryos

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:126871
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace exons 2-4 with a loxP-flanked neomycin resistance (pgk-neo) cassette. This mutation introduced a stop codon before the coiled-coil region (CR1) region of the gene. In order to remove the floxed pgk-neo cassette, heterozygous mutant females were crossed to a CMV-cre male on a mixed C57BL/6-129SV background. (J:126871)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gatad2a Mutation:  108 strains or lines available
Original:  J:126871 Marino S, et al., Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal. PLoS One. 2007;2(6):e519
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory