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Targeted Allele Detail
Symbol: Grntm1Mni
Name: granulin; targeted mutation 1, Masugi Nishihara
MGI ID: MGI:3762618
Synonyms: pgrn-
Gene: Grn  Location: Chr11:102430294-102436809 bp, + strand  Genetic Position: Chr11, 66.29 cM
Germline Transmission:  Earliest citation of germline transmission: J:126370
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 4.7 kb fragment encoding exons 2 - 13 was replaced with a PGK-neo-bpA cassette. RT-PCR analysis confirmed the absence of transcript in the brain, epididymis, testis, lung and liver. (J:126370)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grn Mutation:  31 strains or lines available
Original:  J:126370 Kayasuga Y, et al., Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene. Behav Brain Res. 2007 Dec 28;185(2):110-8
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory