Tg(tetO-Tcf3)1Efu
Transgene Detail

Summary

• Symbol: Tg(tetO-Tcf3)1Efu
• Name: transgene insertion 1, Elaine Fuchs
• MGI ID: MGI:3762570
• Synonyms: Tg(TRE-Tcf3)1Efu, TRE-mycTcf3
• Transgene: Tg(tetO-Tcf3)1Efu Location: unknown
• Alliance: Tg(tetO-Tcf3)1Efu page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Epitope tag, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: Murine Tcf3 cDNA was tagged with an amino-terminal C-myc epitope to distinguish it from endogenous Tcf3. This tagged cDNA was placed under control of a tetracycline regulatory element (TRE) and a CMV minimal promoter. A rabbit beta globin intron was located between the TRE/CMV promoter sequences and the Tcf3 cDNA. The 3' beta-globin UTR was located downstream of the Tcf3 sequence. (J:116057)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:116057 Nguyen H, et al., Tcf3 governs stem cell features and represses cell fate determination in skin. Cell. 2006 Oct 6;127(1):171-83
• All: 7 reference(s)