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Igh-Jtm2(3H9-VDJ*)Mwg
Targeted Allele Detail
Nomenclature
Symbol: Igh-Jtm2(3H9-VDJ*)Mwg
Name: immunoglobulin heavy chain, joining region; targeted mutation 2, Martin Weigert
MGI ID: MGI:3762369
Synonyms: 3H9(56R), 3H9H56R, 3H9H/56R, 56R, 56Rki, VH56R
Gene: Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126940
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThe endogenous DQ52 and all four heavy chain J elements were replaced by a rearranged heavy chain V 3H9 gene encoding an H chain of anti-dsDNA antibody with an amino acid substitution of an arginine for an aspartate at position 56 (D56R) and a neomycin resistance gene. (J:126940)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:  14 strains or lines available
References
Original:  J:126940 Li H, et al., Editors and editing of anti-DNA receptors. Immunity. 2001 Dec;15(6):947-57
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory