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Maddtm1Ytk
Targeted Allele Detail
Nomenclature
Symbol: Maddtm1Ytk
Name: MAP-kinase activating death domain; targeted mutation 1, Yoshimi Takai
MGI ID: MGI:3762127
Synonyms: Rab3 GEP-
Gene: Madd  Location: Chr2:91137360-91183837 bp, - strand  Genetic Position: Chr2, 50.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126869
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe 3' half of exon 1 through the 5' half of exon 2 was replaced with a neo cassette. The lack of protein expression was confirmed by western blot analysis on protein extracted from the brain. (J:126869)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Madd Mutation:  53 strains or lines available
References
Original:  J:126869 Tanaka M, et al., Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction. Mol Biol Cell. 2001 May;12(5):1421-30
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory