About   Help   FAQ
Targeted Allele Detail
Symbol: Cyldtm1.1Awai
Name: CYLD lysine 63 deubiquitinase; targeted mutation 1.1, Ari Waisman
MGI ID: MGI:3761624
Synonyms: CYLDex7/8
Gene: Cyld  Location: Chr8:88697047-88751945 bp, + strand  Genetic Position: Chr8, 43.51 cM
Enlarged spleen and Peyer's patches in Cyldtm1.1Awai/Cyldtm1.1Awai mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:126113
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 7 was removed by cre-mediated recombination and results in an out of frame translation. The absence of a wild-type allele in mouse embryonic fibroblasts was confirmed by RT-PCR using primers located in exon 6 and 9. However, higher levels of an alternative splice form without exons 7 and 8, which is missing the TRAF2 and NEMO binding sites, are produced. (J:126113)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyld Mutation:  22 strains or lines available
Original:  J:126113 Hovelmeyer N, et al., Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD. J Exp Med. 2007 Oct 29;204(11):2615-27
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory