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Targeted Allele Detail
Symbol: Diaph1tm1Sna
Name: diaphanous related formin 1; targeted mutation 1, Shuh Narumiya
MGI ID: MGI:3761498
Gene: Diaph1  Location: Chr18:37843601-37935476 bp, - strand  Genetic Position: Chr18, 19.71 cM
Germline Transmission:  Earliest citation of germline transmission: J:126090
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 1 and a neo cassette flanked by frt sites and containing a 3' loxP site was inserted downstream of exon 1. Insertion was confirmed by PCR and Southern blot analysis. (J:126090)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Diaph1 Mutation:  95 strains or lines available
Original:  J:126090 Sakata D, et al., Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1. J Exp Med. 2007 Sep 3;204(9):2031-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory