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Tg(MMTV-neu/OT-I/OT-II)CBnel
Transgene Detail
Nomenclature
Symbol: Tg(MMTV-neu/OT-I/OT-II)CBnel
Name: transgene insertion C, Brad Nelson
MGI ID: MGI:3761163
Synonyms: MMTV-HER2/Neu-Ovalbumin, neuOT-I/OT-II
Transgene: Tg(MMTV-neu/OT-I/OT-II)CBnel  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(MMTV-neu/OT-I/OT-II)CBnel expresses 1 gene
 
Mutation detailsThe transgene construct was designed to tag T cell receptor-recognized ovalbumin epitopes SIIFEKL (CD8+, OT-1) and ISQAVHAAHAEINEAGR (CD4+, OT-II)with the rat Erbb2/HER-2/neu oncogene under the control of an MMTV promoter creating a fusion protein (termed neuOT-I/OT-II). The vector was injected into C57BL/6 oocytes. Line C was selected for further studies based on mammary-specific expression and favorable tumor latency and frequency. (J:122846)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:122846 Wall EM, et al., Spontaneous mammary tumors differ widely in their inherent sensitivity to adoptively transferred T cells. Cancer Res. 2007 Jul 1;67(13):6442-50
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory