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Unc5btm1Matl
Targeted Allele Detail
Nomenclature
Symbol: Unc5btm1Matl
Name: unc-5 netrin receptor B; targeted mutation 1, Marc Tessier-Lavigne
MGI ID: MGI:3760978
Synonyms: Unc5bbGal
Gene: Unc5b  Location: Chr10:60762594-60831581 bp, - strand  Genetic Position: Chr10, 31.52 cM, cytoband B4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126240
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA secretory trap vector possessing a splice acceptor followed by a linker protein, a transmembrane domain, beta-geo, an IRES domain, and a placental alkaline phosphatase reporter gene was targeted to intron 2 of the gene locus. As a result of integration, exons 1 and 2 splice to the vector sequences resulting in a mutant fusion protein with no biological activity. Northern blots of RNA from E10.5 embryos indicated no wild-type transcript while RT-PCR indicated very low levels (under 3%) of wild-type transcript. (J:126240)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Unc5b Mutation:  2 strains or lines available
References
Original:  J:126240 Lu X, et al., The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004 Nov 11;432(7014):179-86
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory