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Targeted Allele Detail
Symbol: Grin1tm1Nak
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1, Shigetada Nakanishi
MGI ID: MGI:3760845
Synonyms: NR1-
Gene: Grin1  Location: Chr2:25291181-25319187 bp, - strand  Genetic Position: Chr2, 17.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:38582
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a 0.5kb genomic fragment containing coding sequence downstream of the translation initiation site codon. Northern blot analysis on RNA derived from whole brain showed that no detectable transcript is present in homozygous mice. Western blot analysis showed that no encoded protein was present in brain extracts from homozygous mice. (J:38582)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grin1 Mutation:  17 strains or lines available
Original:  J:38582 Tokita Y, et al., Characterization of excitatory amino acid neurotoxicity in N-methyl-D-aspartate receptor-deficient mouse cortical neuronal cells. Eur J Neurosci. 1996 Jan;8(1):69-78
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory