About   Help   FAQ
Ightm1.2Rsky
Targeted Allele Detail
Nomenclature
Symbol: Ightm1.2Rsky
Name: immunoglobulin heavy chain complex; targeted mutation 1.2, Klaus Rajewsky
MGI ID: MGI:3760662
Synonyms: IgHgamma1mu
Gene: Igh  Location: unknown  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125719
Parent Cell Line:  BALB/c-I (ES Cell)
Strain of Origin:  BALB/cJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Intergenic deletion, Inversion
 
Mutation detailsThese mice are derived from chimeric mice produced during creation of the Ightm1.1Rsky mouse strain. Upon crossing the chimeras with Cre expressing transgenic mice, the CH region of the Igh locus is deleted and an inversion of the targeted construct also occurs. This places the mutant Ighg1 into the right orientation to express functional protein. B cells from these mice were found to exclusively express IgG1 antibodies in both a soluble and membrane bound form. (J:125719)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  28 strains or lines available
References
Original:  J:125719 Waisman A, et al., IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta. J Exp Med. 2007 Apr 16;204(4):747-58
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/12/2015
MGI 5.21
The Jackson Laboratory