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Targeted Allele Detail
Symbol: Ightm1.2Rsky
Name: immunoglobulin heavy chain complex; targeted mutation 1.2, Klaus Rajewsky
MGI ID: MGI:3760662
Synonyms: IgHgamma1mu
Gene: Igh  Location: unknown  Genetic Position: Chr12, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:125719
Parent Cell Line:  BALB/c-I (ES Cell)
Strain of Origin:  BALB/cJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Intergenic deletion, Inversion
Mutation detailsThese mice are derived from chimeric mice produced during creation of the Ightm1.1Rsky mouse strain. Upon crossing the chimeras with Cre expressing transgenic mice, the CH region of the Igh locus is deleted and an inversion of the targeted construct also occurs. This places the mutant Ighg1 into the right orientation to express functional protein. B cells from these mice were found to exclusively express IgG1 antibodies in both a soluble and membrane bound form. (J:125719)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  31 strains or lines available
Original:  J:125719 Waisman A, et al., IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta. J Exp Med. 2007 Apr 16;204(4):747-58
All:  1 reference(s)

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