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Ptprbtm1Dgen
Targeted Allele Detail
Summary
Symbol: Ptprbtm1Dgen
Name: protein tyrosine phosphatase receptor type B; targeted mutation 1, Deltagen
MGI ID: MGI:3760508
Gene: Ptprb  Location: Chr10:116111428-116225440 bp, + strand  Genetic Position: Chr10, 64.68 cM, cytoband D2
Alliance: Ptprbtm1Dgen page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125783
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-lacZ-PGK-neo cassette was inserted between exons 17 and 19 replacing exon 18 and its surrounding intronic sequences. Sequences encoding the first six transmembrain domains are replaced. The predicted protein is fused to a beta-galactosidase peptide and lacks the endogenous transmembrane and cytoplasmic domains. The absence of protein product was confirmed by western blot analysis on protein extracts from embryonic endothelioma cells established from E9.5 mice. (J:125783)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptprb Mutation:  99 strains or lines available
References
Original:  J:125783 Baumer S, et al., Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood. 2006 Jun 15;107(12):4754-62
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory