Tg(Tcrb51-11.5)AR1251Ayr
Transgene Detail

Summary

• Symbol: Tg(Tcrb51-11.5)AR1251Ayr
• Name: transgene insertion AR1251, Alexander Y Rudensky
• MGI ID: MGI:3760400
• Synonyms: TCliB, Tg(Tcrb-V6-Tcrb-D-Tcrb-J)AR1251Ayr
• Transgene: Tg(Tcrb51-11.5)AR1251Ayr Location: unknown
• Alliance: Tg(Tcrb51-11.5)AR1251Ayr page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcrb51-11.5)AR1251Ayr expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcrb (MGI:98578)

• Mutation details: The TCRbeta construct consisted of a Vbeta6-Dbeta1-Jbeta2.2 fragment isolated from the hCLIP:I-A^b specific T cell hybridoma 51-11.5. This was microinjected into fertilized (C57BL/6 x DBA/2)F2 eggs. The founder line AR1251 was established. (J:125548)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:125548 Wong P, et al., Competition for specific intrathymic ligands limits positive selection in a TCR transgenic model of CD4+ T cell development. J Immunol. 2000 Jun 15;164(12):6252-9
• All: 5 reference(s)