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Wasltm2Sbs
Targeted Allele Detail
Nomenclature
Symbol: Wasltm2Sbs
Name: WASP like actin nucleation promoting factor; targeted mutation 2, Scott B Snapper
MGI ID: MGI:3760279
Synonyms: N-WASpfl, N-WASP L2L
Gene: Wasl  Location: Chr6:24613810-24664995 bp, - strand  Genetic Position: Chr6, 11.28 cM, cytoband A3
Hypoplasia and loss of glomeruli and proximal tubules in Wasltm2Sbs/Wasltm2Sbs Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ kidneys

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125309
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted downstrem of exon 2 and an additional loxP site upstream of exon 2. The neo cassette was deleted by transient Cre recombinase expression. Insertion was confirmed by Southern blot analysis. (J:125309)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wasl Mutation:  29 strains or lines available
References
Original:  J:125309 Cotta-de-Almeida V, et al., Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15424-9
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory