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Targeted Allele Detail
Symbol: Hspb1tm1Msk
Name: heat shock protein 1; targeted mutation 1, Demetrius Moskophidis
MGI ID: MGI:3760083
Synonyms: hspb1-
Gene: Hspb1  Location: Chr5:135887919-135889563 bp, + strand  Genetic Position: Chr5, 75.51 cM
Germline Transmission:  Earliest citation of germline transmission: J:125325
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation details60% of the coding region from the ATG start codon to exon 2 was replaced with a lacZ and floxed neo cassette. Mice were bred to B6-Cre mice to remove the neo cassette. The absence of protein product was confirmed by western blot analysis of protein extracted from tongue homogenates. (J:125325)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hspb1 Mutation:  10 strains or lines available
Original:  J:125325 Huang L, et al., Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis. 2007 Aug;45(8):487-501
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory