About   Help   FAQ
Hspb1tm1Msk
Targeted Allele Detail
Nomenclature
Symbol: Hspb1tm1Msk
Name: heat shock protein 1; targeted mutation 1, Demetrius Moskophidis
MGI ID: MGI:3760083
Synonyms: hspb1-
Gene: Hspb1  Location: Chr5:135887919-135889563 bp, + strand  Genetic Position: Chr5, 75.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125325
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details60% of the coding region from the ATG start codon to exon 2 was replaced with a lacZ and floxed neo cassette. Mice were bred to B6-Cre mice to remove the neo cassette. The absence of protein product was confirmed by western blot analysis of protein extracted from tongue homogenates. (J:125325)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hspb1 Mutation:  10 strains or lines available
References
Original:  J:125325 Huang L, et al., Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis. 2007 Aug;45(8):487-501
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory