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Cdk4tm2.1Bbd
Targeted Allele Detail
Nomenclature
Symbol: Cdk4tm2.1Bbd
Name: cyclin-dependent kinase 4; targeted mutation 2.1, Mariano Barbacid
MGI ID: MGI:3759558
Synonyms: Cdk4-
Gene: Cdk4  Location: Chr10:127063534-127067920 bp, + strand  Genetic Position: Chr10, 74.5 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125217
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 2 through 4 and a loxP-flanked selection cassette were removed by Flpe-mediated recombination. Removal of the exons was confirmed by Southern blot. (J:125217)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdk4 Mutation:  47 strains or lines available
References
Original:  J:125217 Barriere C, et al., Mice thrive without Cdk4 and Cdk2. Mol Oncol. 2007 Jun;1(1):72-83
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory