Pkhd1^tm1Ggg
Targeted Allele Detail

Summary

• Symbol: Pkhd1^tm1Ggg
• Name: polycystic kidney and hepatic disease 1; targeted mutation 1, Gregory G Germino
• MGI ID: MGI:3759214
• Synonyms: Pkhd1^flox3-4
• Gene: Pkhd1 Location: Chr1:20128003-20688288 bp, - strand Genetic Position: Chr1, 6.27 cM, cytoband A2-A5
• Alliance: Pkhd1^tm1Ggg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125113
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 and 4 were floxed and a neo cassette flanked by frt sites was inserted between exon 4 and 5. PCR was performed to confirm the insertion of the neo cassette. (J:125113)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkhd1 Mutation: 222 strains or lines available

References

• Original: J:125113 Garcia-Gonzalez MA, et al., Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet. 2007 Aug 15;16(16):1940-50
• All: 1 reference(s)