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Tg(TcrLCMV)2Aox
Transgene Detail
Nomenclature
Symbol: Tg(TcrLCMV)2Aox
Name: transgene insertion 2, Annette Oxenius
MGI ID: MGI:3758830
Synonyms: Smarta2
Transgene: Tg(TcrLCMV)2Aox  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TcrLCMV)2Aox expresses 2 genes
 
Mutation detailsTwo expression cassettes, one containing a 17.5 kb Tcr Valpha2.3-JalphaDK1 rearrangement and the other containing a 19.5 kb Tcr Vbeta8.3-Jbeta2.5 rearrangement, were coinjected into fertilized eggs. The injected fragments are specific for the LCMV GP-derived epitope P13 (amino acids 61-80) in the context of H2-IAb. Two transgenic mouse lines (referred to as Smarta1 and Smarta2) were derived from a single transgenic founder. Each sub-line was given its own allele because of phenotypic differences between the sub-lines. The CD4:CD8 ratio of single positive thymocytes for this line is 6:1. (J:92228)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:92228 Oxenius A, et al., Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol. 1998 Jan;28(1):390-400
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory