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Transgene Detail
Symbol: Tg(TcrLCMV)2Aox
Name: transgene insertion 2, Annette Oxenius
MGI ID: MGI:3758830
Synonyms: Smarta2
Transgene: Tg(TcrLCMV)2Aox  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(TcrLCMV)2Aox expresses 2 genes
Mutation detailsTwo expression cassettes, one containing a 17.5 kb Tcr Valpha2.3-JalphaDK1 rearrangement and the other containing a 19.5 kb Tcr Vbeta8.3-Jbeta2.5 rearrangement, were coinjected into fertilized eggs. The injected fragments are specific for the LCMV GP-derived epitope P13 (amino acids 61-80) in the context of H2-IAb. Two transgenic mouse lines (referred to as Smarta1 and Smarta2) were derived from a single transgenic founder. Each sub-line was given its own allele because of phenotypic differences between the sub-lines. The CD4:CD8 ratio of single positive thymocytes for this line is 6:1. (J:92228)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:92228 Oxenius A, et al., Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol. 1998 Jan;28(1):390-400
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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