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Tg(Th-SNCA*)1Mgsp
Transgene Detail
Nomenclature
Symbol: Tg(Th-SNCA*)1Mgsp
Name: transgene insertion 1, Maria Grazia Spillantini
MGI ID: MGI:3758646
Synonyms: TgSyn120
Transgene: Tg(Th-SNCA*)1Mgsp  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Th-SNCA*)1Mgsp expresses 1 gene
 
Mutation detailsThe construct consisted of the sequence expressing human alpha-synuclein 1-120 which is truncated, lacking the final 20 amino acids inserted downstream of the rat tyrosine hydroxylase promoter Th in an expression vector. Vector sequences were removed and the linearized construct was microinjected into fertilized eggs. These mice were crossed to C57BL/6JOlaHsd mice which lack alpha-synuclein as a result of a spontaneous deletion of the alpha-SNCA locus. Immunoblotting demostrated high levels of alpha-synuclein 1-120 in the nigrostriatal pathway and the olfactory bulb in the line 1 founder. (J:108310)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:108310 Tofaris GK, et al., Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. J Neurosci. 2006 Apr 12;26(15):3942-50
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory