Tg(TcraHsv2.3)L118-3Cbn
Transgene Detail

Summary

• Symbol: Tg(TcraHsv2.3)L118-3Cbn
• Name: transgene insertion L118-3, Frank Carbone
• MGI ID: MGI:3758621
• Synonyms: gBT-I.3, Tg(TcraHsv2.3,TcrbHsv2.3)L118-3Cbn
• Transgene: Tg(TcraHsv2.3)L118-3Cbn Location: unknown
• Alliance: Tg(TcraHsv2.3)L118-3Cbn page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraHsv2.3)L118-3Cbn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)

• Mutation details: Rearranged Tcra and Tcrb derived from HSV-1 glycoprotein B specific CTL clone HSV2.3 were placed under the control of a 2 kb fragment of the H-2K^b and a 700 bp fragment including the Igh enhancer. The two constructs were coinjected into F1 embryo zygotes resulting in the establishment of two founder lines. In line L118-3, the two constructs appear to have integrated on separate chromosomes. After backcrossing to C57BL/6, the mouse line referred to as gBT-I.3 was established. This line contains two separately named transgenes. (J:124700)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:124700 Mueller SN, et al., Characterization of two TCR transgenic mouse lines specific for herpes simplex virus. Immunol Cell Biol. 2002 Apr;80(2):156-63
• All: 4 reference(s)